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One-stop disintegrant strategy: Sodium Starch Glycolate meets CMC-Na
Release Time:
Aug 29,2026
There's a recurring myth in oral solid dosage development: one disintegrant is enough. In theory, yes. In practice — especially for high-dose, poorly soluble, or hydrophobic APIs — a single disintegrant often underdelivers on disintegration time, particularly under accelerated stability conditions.
The smarter strategy is a synergistic disintegrant system: Sodium Starch Glycolate (SSG) as the primary superdisintegrant, paired with a controlled level of Sodium Carboxymethyl Cellulose (CMC-Na) to modulate water uptake and wicking.
How the synergy works
- SSG swells rapidly on contact with water, generating the mechanical force that breaks the tablet matrix.
- CMC-Na controls the rate and direction of water penetration, preventing the "gelling lock" that sometimes traps the API inside a swollen shell.
- The result: faster, more reproducible disintegration — even at lower total disintegrant load.
This combination is particularly effective in:
- Orally disintegrating tablets (ODTs)
- High-dose paracetamol and NSAID formulations
- Generic equivalents where bioequivalence margins are tight
What we supply
As an exporter serving regulated and semi-regulated markets, we offer both excipients from our portfolio:
Excipient | Grade | Compendia | Typical Use Level |
Sodium Starch Glycolate | Superdisintegrant, pH-independent | USP / Ph.Eur. / BP | 2–8% |
Sodium CMC-Na | Low / medium / high viscosity | USP / Ph.Eur. | 1–5% |
Both come with:
- Full documentation packages (COA, MOA, residual solvents, microbial limits)
- Stable supply from qualified manufacturers
- Flexible logistics — air, sea, or courier depending on urgency
- Consistent lot performance validated against previous batches
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Tel: +8616639323306
E-mail: info@icasonbio.com
Address: Room 403, Building 7, No. 600 Tongjiang Middle Road, Longhutang Street, Xinbei District, Changzhou City, Jiangsu Province, China
